Biochem/physiol Actions

Reversible: no

Primary TargetCOX-2 activity

Product does not compete with ATP.

Cell permeable: yes

Target IC₅₀: 15.38 µM in blocking glucocorticoid-induced COX-2 activity in human amnion cells

General description

A cell-permeable inhibitor of lipopolysaccaride (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. Blocks LPS-induced tyrosine phosphorylation of a p42^MAPK protein substrate.

A cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. Blocks LPS-induced tyrosine phosphorylation of a p42^MAPK/ERK2 protein substrate. Reduces the expression of iNOS and COX-2 in lungs of rats treated with carrageenan. Blocks glucocorticoid-induced COX-2 activity in human amnion cells (IC₅₀ = 15.38 µM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Cuzzocrea, S., et al. 2000. Am. J. Pathol.157, 145.Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol.77, 138.Kan, H., et al. 1996. Mol. Pharmacol.50, 1139.Novogrodsky, A., et al. 1994. Science264, 1319.

Packaging

5 mg in Alu drum

Warning

Toxicity: Toxic (F)